Early effect of contemporary radiotherapy protocol on myocardium in patients with breast cancer assessed with cardiac magnetic resonance

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): University Medical Centre Ljubljana Research Grant. Introduction Early cardiotoxicity modern radiotherapy (RT) is not known. Purpose To study the early cardiotoxic effect contemporary RT on myocardium with cardiac magnetic resonance (CMR) in patients breast cancer (BC). Methods Patients in-situ ductal carcinoma breast, scheduled for were included. All had undergone surgical tumorectomy. Exclusion criteria prior systemic chemotherapy, or known disease. treated 3-dimensional conformal intensity-modulated RT, left-sided BC also deep inspiration breath hold protocol, if feasible. underwent CMR imaging to and within 2 weeks after RT. Left right ventricular volumes ejection fraction, global native postcontrast T1 values T2 values, completion analyzed. provided written informed consent. Results A total 40 female (mean age 55 ± 7 years) included, 22 BC. The mean radiation dose was 42 Gy. results are presented Table 1. Left-sided statistically significant increase values. There no differences other studied parameters. No patient developed pericardial effusion presence late gadolinium enhancement at both exams. Conclusion Modern associated increased most likely representing myocardial edema,